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The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex
Morning Injections Versus Evening Injections for Weight Loss Morning semaglutide injections work well for patients who eat larger breakfasts or struggle with midday cravings
Metformin has been a long-standing high-value, low-cost agent for metabolic improvement without weight gain but needs progressive dose reduction as GFR falls to avoid nausea or diarrhoea, and should be ceased immediately if a patient is unwell
contraceptive failure The Ozempic babies phenomenon (unintended pregnancies associated with GLP-1RAs) is consistent with an epidemiological explanation: metabolic improvement triggers the recovery of ovulatory function while contraceptive strategies lag, leading to increased unintended pregnancies
